DENSS

DENsity from Solution Scattering

  • About DENSS
  • Download
  • Install
  • Tutorial
    • Introduction
    • Basic Usage
    • Averaging with DENSS
    • Averaging with EMAN2
    • Advanced Usage
    • Tips
  • News

DENSS now deals with enantiomers

February 28, 2018 by Tom Grant

One of the problems with solution scattering is that enantiomers (mirror images of a particle) yield identical scattering profiles. For some particle shapes this can prove to be a serious problem resulting in opposite enantiomers being averaged during the averaging procedure. The superdenss script now includes a new option (-e) that can be used to generate all possible enantiomers for each reconstruction of denss.py and select the enantiomer that best fits the reference model. To learn how to use the option, visit the Tutorials page.

DENSS reconstruction of correct enantiomer from simulated SAXS data of PDB 4FE9
DENSS reconstruction of incorrect enantiomer from simulated SAXS data of PDB 4FE9
Averaged DENSS reconstruction of PDB 4FE9 using enantiomer selection

Filed Under: Developments, News

Contact the Author:

  • Email
    tdgrant@buffalo.edu
  • Phone
    (716) 829-5490
  • Address
    Jacobs School of Medicine and Biomedical Sciences
    SUNY University at Buffalo
    955 Main Street
    Buffalo, New York, USA 14203

Contact the Author:

  • Email
    tdgrant@buffalo.edu
  • Phone
    (716) 829-5490
  • Address
    Jacobs School of Medicine and Biomedical Sciences
    SUNY University at Buffalo
    955 Main Street
    Buffalo, New York, USA 14203

Copyright © 2025 · AgentPress Pro on Genesis Framework · WordPress · Log in